This systematic review and meta-analysis aimed to assess the global prevalence of CD in patients with type 1 diabetes.

This meta-analysis evaluates the response to placebo across multiple outcome domains in eosinophilic oesophagitis trials. While > 40% of patients improve clinically on placebo (influenced by patient age and randomisation ratio), most patients do not improve histologically or endoscopically, highlighting the importance of objective disease assessment.

Despite the prevalence and quality of life impact cramps have on patients with cirrhosis, no widely used clinical practice guidelines on management exist. Our systematic review, focusing only on randomised controlled trials, evaluates a number of interventions within their contextual factors to provide a clinically focused summary on this subject.

The increasing prevalence of IBD, with an inevitable increase in the number of visits, instrumental examinations and laboratory testing, also poses a problem of environmental sustainability. Long-term strategies in clinical, diagnostic and therapeutic management are possible to mitigate the “carbon footprint” of IBD.

In this pivotal study (SHUNT-V) in patients with Child–Pugh A cirrhosis, we report the diagnostic performance of the HepQuant SHUNT and DuO tests of liver function and physiology for ruling out large oesophageal varices and detecting significant lesions of portal hypertension.

The study demonstrates the effectiveness of individualized HCC surveillance using risk -stratification scores in advanced fibrosis and cirrhotic HCV patients who achieved SVR. It shows improved detection rates of early-stage HCC, highlighting the importance of tailored screening intervals based on patient risk levels.

A population-based cohort study assessing amongst patients diagnosed with cirrhosis in the hospital, the impact of outpatient follow-up within 90 days on 1-year mortality and 1-year rehospitlization rates.

The Australian Inflammatory Bowel Disease (IBD) Consensus Working Group developed consensus statements on pre-treatment assessments and vaccinations prior to the initiation of advanced therapies for IBD. These statements aim to provide clinicians with clear guidance on managing IBD patients.

In Lynch syndrome, faecal volatile organic compounds (VOCs) showed 89%–100% sensitivity and 54%–58% specificity for colorectal cancer and advanced adenomas, and differed before and after adenoma removal (AUC 0.70). Faecal VOCs might guide optimal colonoscopy intervals in Lynch syndrome, aiming to reduce colonoscopy overuse and post-colonoscopy colorectal cancer rates.

Among 658 faecal microbiota transplantation (FMT) performed in 17 centres in France from 2018 to 2022 for Clostridioides difficile infection (CDI), severe chronic kidney disease, non-severe refractory CDI, the use of ≥ 80% glycerol, insufficient bowel cleansing and partial FMT retention were associated with CDI recurrence within 8 weeks.

We validated the Sundaram-ACLF-LT Mortality (SALT-M) score in a large-volume, Asian single-centre cohort, analysing 224 patients of acute-on-chronic liver failure (ACLF) grade 2–3. SALT-M outperformed previous MELD systems for predicting posttransplant mortality in an Asian LT cohort, with an area under the receiver operating characteristic curve of 0.691. Transplantability for patients with severe ACLF could be determined based on SALT-M.

Patients with Hospital Anxiety and Depression (HADS)-D scores ≥ 8 were significantly less likely to respond to dietary intervention for irritable bowel syndrome (IBS) (43.8% vs. 64.0%, p < 0.01). There was a trend towards superiority among patients with HADS-A scores < 8 (53.4% vs. 62.2% p = 0.09). Understanding psychological profiles can help predict patients response to IBS dietary interventions.