We present a report on SHORT syndrome caused by PIK3R1 mutations, including findings from in silico analysis. Our results demonstrate that these mutations impair the ability of p85α to interact with phosphopeptides.

Advocacy efforts to reduce the burdens of people with diabetes are growing. However, the situation varies significantly across countries and in our Asia–Pacific region. Through mutual understanding and collaboration, we aim to strengthen advocacy efforts across the Asia–Pacific region and contribute to global initiatives that enhance health outcomes for people with diabetes.

Multiple regression analysis revealed that diuretic use was an independent risk factor for discontinuation of SGLT2i.

The burden of young-onset type 2 diabetes is increasing globally, disproportionately affecting non-White ethnic groups and low- and middle-income countries. Young-onset type 2 is more heterogeneous regarding the genetic and environmental contributions to its underlying pathophysiology, which poses challenges for glycemic management. This review summarizes recent studies on the epidemiology of young-onset type 2 diabetes and its complications, discusses the genetic and environmental risk factors, and provides insights on diabetes prevention and management to address the unique medical and psychosocial issues associated with young-onset type 2 diabetes.

COVID-19 is associated with a long-term increased risk of amputation, persisting for more than 2 years post infection. These findings highlight the need for vigilant vascular monitoring and early intervention to mitigate the long-term complications of COVID-19.

This finding reveals the important role of Uhrf1 in the β-cell dedifferentiation of T2D, providing a potential target for its treatment.