our current work indicated that the silencing of TCF7 attenuated HG-induced injury in human podocytes at least in part through regulating SEMA3A expression via sponging miR-16-5p. These findings provided a new insight into the molecular mechanism for HG-induced podocyte damage.

Suramin, a nonselective antagonist of the P2 receptors, suppresses NLRP3 inflammasome activation and exerts renoprotective effects in diabetic KK-Ay mice. Suramin protects against DKD development via the inhibition of P2X receptors, and can be expected to be an important drug for the treatment of DKD.

We aimed to assess possible association between TCF7L2 genotypes (rs7903146) and characteristics of type 1 diabetes including autoantibodies and C-peptide levels. Our findings about the association of TCF7L2 polymorphism with zinc transporter 8, islet antigen 2 autoantibodies and C-peptide levels in patients support the view that TCF7L2 may contribute to development of type 1 diabetes. The interaction between the TCF7L2 risk genotype and autoantibodies needs to be studied further.

Selenoprotein P (encoded by SELENOP in humans) is a hepatokine that causes impaired insulin secretion and insulin resistance. We found that higher baseline levels of selenoprotein P significantly predicted a hypoglycemic effect and recovery of insulin secretion under metformin therapy. Selenoprotein P might be a novel biomarker for predicting the effect of metformin therapy, and could potentially be the first “tailor-made” diabetes treatment.

This study shows findings from a systematic review of RCTs and non-RCTs published in the past 10-years on adult subjects with suboptimally controlled type 2 diabetes (T2D) despite receiving one or more glucose-lowering drugs in Japan. The characteristics of studied subjects were different among study designs. Our study also found that subjects with older age and comorbidities were rarely included in both RCTs and non-RCTs.

This network meta-analysis of 107 trials and nearly 9,000 participants provided conclusions on the rankings of popular dietary patterns for glycemic control, weight, blood pressure, and serum lipid profile outcomes. For each outcome, clinicians can use this work to find the most appropriate and effective diet, benefiting from this study. Heterogeneity and sensitivity should be considered, and more high-quality RCTs for new dietary patterns are needed.

In this study, a total of 247 T2DM patients were enrolled and they all received carotid ultrasonography and quantitative sensory testing which indicates the function of small fiber nerve. And the correlation between these two parameters were analyzed by SPSS 26.0. Finally, we found that carotid atherosclerosis was significantly associated with quantitative sensory testing and found to be an independent risk factor for small fiber nerve damaging in T2DM. This study is benefit to the prevention and early diagnosis of diabetes complication especially small fiber neuropathy.

This study proved that ML models have predictive performance as good as traditional statistical analysis. Most importantly, this study can provide effective key information in predicting the risk of developing diabetes, which guides the research on other chronic diseases.

The COVID-19 pandemic had a negative impact on the glycemic control and body composition of people with diabetes mellitus. The increased body weight and fat mass and decreased skeletal muscle mass observed during the pandemic were associated with poor glycemic control in people with diabetes mellitus.

In an analysis using cancer registry and DPC data of Japanese patients with cancer, coexisting diabetes was associated with increased mortality and risk of developing a second primary cancer.

Our results showed that different baseline GGT groups were still significantly associated with increased FBG levels during follow-up. The annual mean increase in FBG levels showed a positive relationship with baseline GGT levels. This trend was even more aggregated in the highest baseline GGT group. GGT can be used for the early detection of FBG-related disorders of glucose metabolism for clinical application.

After CBT, we noted elevated FBS levels and positivity for anti-GAD antibodies (25.6 U/mL). The patient developed an insulin-dependent state as the C-peptide immunoreactivity index decreased with time.